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The drug competitively inhibits muscarinic receptors, particularly peripheral M3 receptors in the gastrointestinal tract and salivary glands, thereby reducing parasympathetic cholinergic effects

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HIV-infected leukocytes can then infect the healthy brain that would have been otherwise blocked by the BBB and begin to directly cause neuronal dysfunction by inducing chronic inflammation or neuronal degeneration via Gp120, Tat, and VPR proteins [4]