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Moreover, ectopic expression of a constitutive active form of PKD3 (PKD3ca) in TNBC (triple-negative breast cancer cells) leads to hyperphosphorylation of S6 Kinase 1 (S6K1), a downstream target of the mechanistic target of rapamycin complex 1 (mTORC1), which is an energy sensor in the cell and sustains cell proliferation (Laplante & Sabatini, 2012
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