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Another possibility is the involvement of membrane transporters to transport the alkaloids

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Conditions such as atrophic gastritis (thinning of the stomach lining), Pernicious anemia (which makes it harder for your body to absorb Vitamin B12), Intestinal diseases such as crohn’s disease, celiac disease, bacterial growth and immune system disorders such as Grave’s disease or lupus can lead to Vitamin B12 deficiency in the body