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On the other hand, the high GSH concentration observed under atrophy could impede the redox-mediated signaling pathways necessary for muscle homeostasis (i.e., aged differentiated muscle cell replacement by stem cells that assures muscle functionality)

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The molecular mechanism leading to the Nrf2 loss phenotype is not fully understood, but our data suggest that Nrf2/AP-1 tight transcriptional regulation plays an important role in thyroid maturation and function