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These approaches may act through multiple pathways—such as modulating the gut microbiota, regulating immune responses, and enhancing metabolic functions—thus offering novel therapeutic avenues for ASD ( 4.1 Gluten-free and casein-free diets The gluten-free and casein-free (GFCF) diet is among the most widely implemented nutritional interventions for ASD, based on the hypothesis that opioid-like peptides derived from gluten and casein may affect brain function (Önal et al., 2023)