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Endometriotic lesion growth can be promoted via multiple intrinsic pathways, including not only estrogen and PI3K/AKT/mTOR as aforementioned, but also mitogen-activated protein kinases (MAPK)/mitogen-activated protein kinase kinase/extracellular-signal-regulated kinases and nuclear factor-kappa B (33,34), while it may also be influenced by extrinsic factors such as iron overload and hypoxia (16,35,36)
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