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Once in the cortex, upregulation of KCC2 is necessary for the reduction of interneuron motility through the drop of neuronal chloride, a process which is also a precondition for the inhibitory effects of the neurotransmitter GABA and glycine in the CNS (Yeo et al., 2013)

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Therefore the increased amounts of extracellular glutamate may reflect increased cystine uptake