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Drugs are transported through blood sinusoids by various mechanisms, including organic anion and cation transport proteins of the basolateral membrane, other transport proteins such as Na+-taurine bile acid co-transporting polypeptides or prostaglandin transport proteins, and passive diffusion, before metabolism and clearance within hepatocytes (48)
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Metformin, a first-line oral antidiabetic agent, has also been reported to alleviate hepatotoxicity induced by ATO (Ling et al., 2017) and sodium arsenite-induced hepatic mitochondrial toxicity (Ahangarpour et al., 2017) by modulating mitochondrial function
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