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(106), the mTOR pathway increases GPX4 protein synthesis and sterol response element binding protein (SREBP)-mediated lipogenesis to encourage resistance to ferroptosis (107)

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Under the therapeutic concentrations, approximately 60%–90% of APAP is metabolized in the liver by glucuronidation and sulfation, with a small part (approximately 5%–15%) being metabolized by the cytochrome P450 pathway (CYP450) (Kalsi et al., 2011

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