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Glutathione: A Most Powerful Antioxidant - Carriage House Medicine | Dr. Jennifer Reid

Unlike prior studies emphasizing single-organ effects, our analysis reveals that ferroptosis drives a self-reinforcing cycle: Hyperglycemia in DM triggers systemic iron overload, and the accumulation of iron in peripheral organs, combined with oxidative stress imbalance, causes organ damage (including pancreatic β-cells), further exacerbating the progression of DM and forming a pathological feedback loop

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However, their clinical effectiveness is typically limited due to the convergence of kinase signaling networks and epigenetic regulators, which often collaborate to enhance drug resistance [6]