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In T cells, TGF-β serves as a key immunoregulatory cytokine that can direct T-cell differentiation toward either tolerogenic or inflammatory lineages, promoting the development of Tregs or, in the presence of pro-inflammatory cytokines such as IL-6 or IL-21, inducing Th17 cells 52

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The two meta-analyses are complementary — Pei confirms the overall effect with greater certainty, while Xu provides practical guidance on optimal parameters