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2.1 Hormonal factors Hormonal regulation is another important risk factor that plays a crucial role in breast cancer development, progression, and therapeutics ( Estrogen, a steroid hormone, is predominantly synthesized in ovaries until menopause and in adipose tissue post-menopause ( Hormonal exposure is further modulated by several factors, such as reproductive factors

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Another study demonstrated that the ID1/Wnt/β-catenin signaling cascade regulates the attachment of c-Myc with the G6PD promoter and increases the transcription of G6PD , resulting in enhanced cell proliferation and drug resistance for oxaliplatin in hepatocellular carcinoma (HCC) [70]