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Moreover, the classical features of ferroptosis, such as elevated lipid peroxidation, extracellular signal-regulated kinase (ERK) activation and amplified neuroinflammation, were also observed and treatment with a ferroptosis inhibitor could ameliorate neurodegeneration in those mice (Hambright et al., 2017)
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Translating these in vitro findings to an in vivo model, naturally aged male mice from 20-24 months old were treated with FOXO4-DRI
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