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A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the international initiative for accelerated improvement of glioblastoma care
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Ribose-5-phosphate is converted to 5-phospho-ribosyl-a-1-pyrophosphate (PRPP), which then is catalyzed by phosphoribosyl pyrophosphate amidotransferase (PPAT) to generate phosphoribosylamine (5PRA), a rate-limiting step in the de novo purine biosynthetic pathway
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