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Inside that outer ring sits the nucleus pulposus , a gelatinous core rich in type II collagen, elastin fibers, and a hydrated proteoglycan gel that gives the disc its shock-absorbing properties

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In response to oxidative stress or other situations when more GSH is required, the expression of GCL is regulated through two redox sensitive signaling pathways comprised of Nrf2-EpRE system and AP-1 [25, 26]