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Overexpression of glutathione S-transferase and elevation of thiol pools in a multidrug-resistant human colon cancer cell line Mol Pharmacol 1992 41 : 69–75 Smith MT, Evans CG, Doane-Setzer P, Castro VM, Tahir MK, Mannervik B
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In the absence of functional APC, β -catenin accumulates in the cytoplasm, then enters the nucleus and activates transcription of various genes, leading to constitutive activation of the Wnt signaling pathway
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