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The oral NMDA receptor positive allosteric modulator zelquistinel (AGN-241751, GATE-251) [100] was investigated in a phase 1/2 trial (NCT03726658) and a phase 2 trial (NCT03586427) for the treatment of MDD, but the studies did not meet their primary efficacy endpoints

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We performed a “discovery” genome-wide association study using a cell line–based model system to study the possible contribution of genomics to NAPQI-induced cytotoxicity