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This typically includes: Detailed clinical examination and full medical history review Blood tests: complete blood count, iron studies, B12, folate, zinc levels Autoimmune screen ANA, anti-dsDNA, and other markers if systemic disease is suspected Coeliac antibody testing tissue transglutaminase IgA (tTG-IgA) Allergy testing if specific food or contact triggers are suspected Biopsy for persistent, large, or atypical ulcers to exclude malignancy A personalised investigation plan is designed based on the frequency, severity, and associated symptoms
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Decreased expression of MT-1 can also assist in the diagnosis of hepatocellular carcinoma to a certain extent [71]
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