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If a serious complication arose (say, an immune reaction or a cancer diagnosed down the line), the patient might argue they weren’t properly warned because the doctor themselves could not know the risks

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The following period (1958–1985), during which pituitary-derived human GH was used, generated a wealth of information on the regulation and physiological role of GH — in conjunction with insulin-like growth factors (IGFs) — and its use in children with GH deficiency (GHD)