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The histopathological evaluation at the early remyelination phase revealed that the VA group and IBD group demonstrated only partial demyelination in the CC nerve fibers with few instances of splitting in the myelin fibers (Figures 12E,G,I), whereas the CPZ-treated group showed a significant decrease in the intensity of LFB staining in the CC, with most fibers appearing disordered and light in color (Figure 12C)
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clinical effect sizes vary by indication, dosing, individual factors, and adherence
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