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subcutaneous adipose tissue preference Reduction in adipocyte size: 25–351 TP3T cell diameter Adipocyte apoptosis: increased programmed cell death in pathological fat tissue Adiponectin: Increased secretion of the anti-inflammatory adipokine Pharmacokinetics SC Bioavailability: 80–85% Absorption: rapid, Tmax 20–30 minutes Half-life: 30–60 minutes (short) Distribution: preferential adipose tissue Elimination: rapid renal clearance, with no active metabolites Duration of effects: 4–6 hours after administration 🔹 Applications, Mechanisms, and Extended Research SELECTIVE BODY FAT REDUCTION Weight Loss and Visceral Fat: Preclinical Rodent Studies: Body weight reduction: 50–55% higher than controls (12 weeks, obese rats) Visceral fat: reduction with 65-70% vs

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10.1016/j.ejphar.2014.01.046 31 DuzelA.VlainicJ.AntunovicM.MalekinusicD.VrdoljakB.SamaraM.et al (2017)