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FIGURE 3 After acute tendon injury, the metabolic level during tendon healing increases after injury, and leads to tendon hypoxia (increased HIF-1) because the tendon is almost avascular ( via nerve-derived VEGF in tendons harbor more perivascular cells (also called pericyte), which are the source of tendon stem/progenitor cells (TSPCs) that exhibit mesenchymal stem cell-like characteristics, including self-renewal and regeneration, mediating tendon injury healing ( Due to the regular changes of VEGF after tendon injury, some studies have proposed that VEGF and neovascularization are considered as observational indexes and predictors of clinical efficacy in patients with tendon injury before and after treatment ( Despite the various benefits of VEGF in promoting angiogenesis for tendons, there is still some literature suggesting that VEGF impairs tendon healing, such as mechanical properties and pain
CHCHIRO
Quantity:12 pairs
Metformin, a drug usually used for the treatment of type 2 diabetes, has demonstrated anti-cancer properties