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Consistent with increased depressive-like behaviors in DOR KO mice (Figure 1), studies have shown that DOR receptor activation by several agonists has antidepressant-like effects across four behavioral paradigms in both rats and mice: LH, FS, tail suspension (TS) and olfactory bulbectomy (see Table 1 and [31-49])
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Synthesizing available evidence, IS and pCS possess relatively complete evidence chains (encompassing Levels 1–3 evidence), whereas PAGln and certain BCAA derivatives require additional empirical research for verification
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