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Nicotine exposure, a key component of TS, has been found to downregulate the expression of TJ proteins such as ZO-1, occludins, and cadherins, leading to an increased BBB permeability [276, 277]
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In addition, a GLP fraction increases in the number of DCs as well as CD4, CD8, regulatory T, B, plasma, NK and natural killer T (NKT) cells in the spleen of mice
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