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Accordingly, administration of milrinone, a PDE III inhibitor, to Wistar rats before noise over-exposure, ameliorates vacuolization, inflammation, and apoptotic processes in the sensory epithelium and the SV as compared to untreated rats (Ceylan et al., The micronutrient Mg 2+ also has been proposed as a treatment for NIHL, not only for its function as a potential cochlear vasodilator but for other pharmacological properties, which include modulation of NMDA glutamate receptors and the regulation of calcium influx into hair cells, preventing or reducing apoptosis (Cevette et al., 2+ for one month enhanced hair cell survival and reduced significantly the auditory threshold shift in noise-exposed guinea pigs (Abaamrane et al., 2+ alone 1 h before and up to 5 days after noise stimulation in guinea pigs, did not show reliable effects over noise over-exposure
