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For example, in some embodiments, the polynucleotides of the present invention are used in methods of administering a polynucleotide encoding a lysosomal enzyme in combination with a pharmacological chaperone or glucosylceramide synthase inhibitor to a subject, wherein the method results in an increase of lysosomal enzyme expression and/or enzymatic activity in at least some cells of a subject
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I recommend both of those in the appendix of my book, Dirty Genes
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