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3,4 COMT inhibitors inhibit the breakdown of dopamine and of levodopa in the body, thus prolonging their therapeutic effect and time spent in ‘ON’… Other medications used in the treatment of Parkinson’s disease (IV) Certain non-dopaminergic agents help to reduce dyskinesias, 6 but have the limitation of worsening side effects, such as hallucinations and psychosis, in some individuals

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Vitamin B-12 also plays a role in the synthesis of neurotransmitters