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This protective effect appears to involve alterations in the RANKL/OPG ratio, suggesting that persistent HIF-1α activation may help preserve bone mass under certain conditions (Kelly et al., 2013), while pharmacological activation of HIF-1α induces expression of LL-37 (and its murine homolog CRAMP), enhancing bactericidal activity ( S

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Pregnant or breastfeeding women should avoid lipotropic injections unless specifically prescribed for documented B12 deficiency