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By acting as a copper chelator, GSH binds mitochondrial Cu + into an inert complex, thereby blocking its interaction with lipoylated proteins ( 3.2 Cuproptosis in OSCC: from tumor suppression to immune landscape shaping Although research on cuproptosis in OSCC is still nascent, accumulating evidence underscores its pivotal role in regulating core malignant behaviors of OSCC cells, such as proliferation, apoptosis, migration, and invasion

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