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Although it exhibited a low tendency to aggregate at high concentrations, no significant complications were observed during filter-protein concentration or dialysis, which was performed either to change the buffer or to remove imidazole after protein purification

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After applying the inclusion and exclusion criteria, 69 patients were excluded, including those with incomplete clinical data ( n = 13), coexisting autoimmune diseases ( n = 16), active infections ( n = 10), pregnancy or lactation ( n = 17), and participation in other clinical trials ( n = 13)