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Western blot analysis of purified glutathione S-transferase (GST)–free... | Download Scientific Diagram
In addition, we have further shown that PDI also plays an important role in mediating RSL3-induced ferroptotic cell death in HT22 cells because RSL3 is a strong inhibitor of TrxR1 20 , and inhibition of TrxR1 activity would keep more PDI molecules in the catalytically-active oxidized form and thus facilitate NOS dimerization and ferroptotic cell death 21,29
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